Comparing Two Healthcare Investment Powerhouses
For investors looking to gain exposure to the healthcare sector, the Fidelity MSCI Health Care Index ETF (FHLC) and the State Street Health Care Select Sector SPDR ETF (XLV) are two of the most prominent choices. While both funds are highly cost-efficient, maintaining a matched 0.08% expense ratio, they employ fundamentally different strategies that cater to varying investment goals.
Understanding the Strategic Differences
The primary distinction between these two ETFs lies in their portfolio composition and market-cap focus:
- State Street (XLV): Launched in 1998, this fund focuses strictly on the healthcare components of the S&P 500. With 60 large-cap holdings, it offers a concentrated approach that prioritizes blue-chip stability and high liquidity.
- Fidelity (FHLC): Launched in 2013, this ETF tracks the MSCI USA IMI Health Care Index. It offers significantly broader diversification with 365 holdings, capturing not only large-cap stocks but also mid- and small-cap companies that are absent from the XLV portfolio.
Performance, Yield, and Risk
The differences in holdings naturally lead to different performance profiles. XLV is heavily weighted toward industry giants; for instance, more than 25% of the fund is concentrated in just two companies: Eli Lilly & Co and Johnson & Johnson. This concentration makes the fund’s performance closely tied to the results of these specific corporations.
For income-oriented investors, XLV currently offers a higher trailing-12-month dividend yield of 1.7%, compared to 1.4% for FHLC.

Conversely, FHLC’s inclusion of smaller, faster-growing companies may appeal to investors looking for broader sector participation and potential growth. However, this diversification comes with a trade-off: smaller companies often exhibit higher volatility. Consequently, FHLC has historically shown a higher beta and maximum drawdown compared to the more conservative, large-cap-focused XLV.
Which ETF Should You Choose?
The decision between these two funds generally depends on an investor’s risk tolerance and income requirements:
- Choose XLV if: You prefer a conservative, long-term “buy and hold” strategy, prioritize current income through dividends, and want exposure to established, highly liquid blue-chip healthcare companies.
- Choose FHLC if: You are seeking comprehensive exposure to the entire healthcare ecosystem, including the growth potential of mid- and small-cap companies, and are comfortable with higher volatility in exchange for the possibility of greater returns.
Both funds represent efficient ways to gain targeted exposure to the pharmaceutical, biotechnology, and healthcare equipment industries, but their distinct approaches to diversification mean that one may be significantly better suited to your specific financial objectives than the other.


